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Faculty: William A. Fonzi
Emeritus Faculty
“Microbial pathogens confront diverse environments within the human host. Rapid adaptation to the physiochemical, nutritional, and other variables within these environments is paramount to the pathogen’s ability to survive and cause disease. Defining the nature of these adaptations and understanding how they contribute to virulence of the pathogen will suggest new targets for intervention and prevention of infections.”
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Faculty: Michael F. Cole
Professor
“The major focus of my laboratory is understanding the way in which the mucosal immune system interacts with the commensal microbiota of the oropharynx. The research team pursues longitudinal studies of mother-infant pairs from birth to age two years examining the diversity of streptococci and secretory IgA antibodies in saliva.”
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Faculty: John L. Casey
Associate Professor
“My laboratory is investigating the molecular biology of viral hepatitis. Current efforts are focused on the molecular biology of hepatitis delta virus (HDV), a unique human pathogen that causes severe liver disease. There are 10 – 15 million people infected with HDV worldwide, and there is currently no therapy. The 1680nt circular HDV RNA genome is the smallest known to infect man, and produces just one protein. It is thus not surprising that HDV relies heavily on host functions and that its RNA is replete with unusual functional properties. These properties make investigating this virus particularly interesting and rewarding for both molecular virologists and RNA biologists.”
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Faculty: Richard Calderone
Professor & Chair
Richard Calderone, PhD, is Chair of the Department of Microbiology and Immunology and Director of the MS Degree Program in Biomedical Science Policy & Advocacy at The Georgetown University Medical Center. He is an internationally recognized leader in research on the human pathogen Candida albicans, the pathogenesis of invasive candidiasis, and the identification of antifungal drug targets. The research of his lab team is focused primarily on understanding gene functions related to pathogenesis, including signal transduction proteins related to cell wall synthesis, and mitochondrial energetics. Other lab research focuses upon the identification of fungal-specific antifungal drug targets. Two proteins that fulfil this requirement are mitochondrial electron transport complex I (ETC1) subunits. Their fungal gene-specificity is associated with fungal-specific functions, such as cell wall mannan polysaccharide synthesis, virulence, and immunological activity.
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Professor Emeritus: Joseph A. Bellanti
Dr. Joseph A. Bellanti is Director of the International Center for Interdisciplinary Studies of Immunology at Georgetown University Medical Center and Professor of Pediatrics and Microbiology-Immunology, (Emeritus) at Georgetown University School of Medicine, Washington, DC.
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Video: Dr. Joseph A. Bellanti
Visit www.immunologycenter.org for more information about Immunology IV
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"Hepatitis Affects Everyone, Everywhere”
Four researchers in the Department of Microbiology and Immunology are key to efforts by drug developers in the U.S. and internationally to prevent or treat three viruses that sound like cousins, but which are not — hepatitis B, C, and D.
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Research Facilities
The department occupies more than 12,000 square feet in the Medical-Dental Building and has access to additional facilities in the Lombardi Comprehensive Cancer Center. In addition to the library and
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Faculty
Learn from experts in field of microbiology and immunology and participate leading research.
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About
Microbiology and Immunology: Essential Fields in a Ever-Changing World As the COVID-19 pandemic has demonstrated, It is not possible to adequately protect the health of our nation without addr
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