Faculty: Richard Calderone

Dr. Richard Calderone is Professor & Chairman of the Department of Microbiology & Immunology. Director of the M.S. program in Biomedical Science Policy & Advocacy.

Summary:
  • Ph.D., West Virginia University, 1970
  • At Georgetown Since: 1974
  • Current lab has capacity for both new Ph.D. students and Post Doctoral Fellows
  • Contact: (202) 687-1513; calderor@georgetown.edu
Details:

The focus of research in the Calderone laboratory is on the two most common fungal pathogens of immunocompromised patients, Candida albicans and Aspergillus fumigatus. We use molecular biological and biochemical approaches to identify new targets on these fungi that can be exploited in drug discovery. In this regard, the potential drug targets that have been identified are two-component signal transduction proteins. In addition, in C. albicans, we study DNA repair and again focus upon identifying unique proteins that may have potential as drug targets. Our collaboration with a medicinal chemist has resulted in 4 compounds in patent that we hope to further develop. The lab is supported by NIH funds and the research staff in the lab currently includes 2 PhD students and 2 research Assistant Professors and a post-doctoral fellow. (Has both potential capacity for new doctoral students and/or research staff.)

Publications:
  • Li D, Chen H, Florentino A, Alex D, Sikorski P, Fonzi WA, Calderone R. Eukaryot Cell. 2011 May;10(5):672-82. Enzymatic Dysfunction of Mitochondrial Complex I of the Candida albicans goa1 Mutant Is Associated with Increased Reactive Oxidants and Cell Death.
  • Andaluz E, Bellido A, Gómez-Raja J, Selmecki A, Bouchonville K, Calderone R, Berman J, Larriba G. Mol Microbiol. 2011 Mar;79(6):1462-82. Rad52 function prevents chromosome loss and truncation in Candida albicans.
  • García-Prieto F, Gómez-Raja J, Andaluz E, Calderone R, Larriba G. Fungal Genet Biol. 2010 May;47(5):433-45. Role of the homologous recombination genes RAD51 and RAD59 in the resistance of Candida albicans to UV light, radiomimetic and anti-tumor compounds and oxidizing agents.
  • Li, D, Agrellos, O., and R. Calderone. 2010. Current Opinion in Microbiology. Histidine kinases keep fungal pathogens free of stress.
  • Bambach A, Fernandes MP, Ghosh A, Kruppa M, Alex D, Li D, Fonzi WA, Chauhan N, Sun N, Agrellos OA, Vercesi AE, Rolfes RJ, Calderone R. Eukaryot Cell. 2009 Nov;8(11):1706-20. Goa1p of Candida albicans localizes to the mitochondria during stress and is required for mitochondrial function and virulence.
  • Li D, Williams D, Lowman D, Monteiro MA, Tan X, Kruppa M, Fonzi W, Roman E, Pla J, Calderone R. Fungal Genet Biol. 2009 Oct;46(10):731-41. The Candida albicans histidine kinase Chk1p: signaling and cell wall mannan.
  • Menon V, De Bernardis F, Calderone R, Chauhan N. Transcriptional profiling of the Candida albicans Ssk1p receiver domain point mutants and their virulence. FEMS Yeast Res. 2008 Aug;8(5):756-63. Epub 2008 Jul 8.
  • Walia A, Calderone R. The SSK2 MAPKKK of Candida albicans is required for oxidant adaptation in vitro. FEMS Yeast Res. 2008 Mar;8(2):287-99. Epub 2007 Dec 17.
  • Gómez-Raja J, Andaluz E, Magee B, Calderone R, Larriba G. A single SNP, G929T (Gly310Val), determines the presence of a functional and a non-functional allele of HIS4 in Candida albicans SC5314: detection of the non-functional allele in laboratory strains.  Fungal Genet Biol. 2008 Apr;45(4):527-41. Epub 2007 Sep 21.

Medline publications list