Two New Publications Focus on Dengue Virus and Antifungal Drug Discoveries.

Two faculty members in the Department of Microbiology and Immunology have made significant contributions in the areas of the Dengue Virus and Antifungal Drug Discoveries.  

Dr. Radhakrishnan Padmanabhan, Department of Microbiology and Immunology at Georgetown University and Dr. Subhash Vasudevan of Duke-National University of Singapore  are editors of the book, "Dengue: Methods and Protocols". The book  offers detailed descriptions of techniques compiled from the leading laboratories working on dengue research. Each year, Dengue virus (DENV1-4) infects millions of people  in tropical and subtropical regions of the world. Children are particularly vulnerable to the effects of the virus. Currently, there is no preventive vaccine or antiviral drugs for treatment. 

Dr. Richard Calderone, Professor of Microbiology and the Chair of the Department of Microbiology and Immunology, was the first author on the journal article, "Antifungal drug discovery: the process and outcomes", which appeared in the Future Microbiology Journal. The article highlights the impending crisis of invasive fungal infections.  Currently, mortality due to invasive fungal infections globally equals that caused by drug-resistant tuberculosis and exceeds deaths due to malaria.  In spite of this, no new antifungal therapeutic interventions have occurred during the past 2 decades.  This review summarizes the the public health issues of these diseases, advocacy and policy to promote new discovery, and basic research currently underway, including in the Calderone lab, to develop new antifungal drugs.