Faculty: Paul J. Cote

Dr. Cote is a Research Professor of Microbiology & Immunology

Summary

  • M.S., Physiology, Pennsylvania State University, 1977
  • Ph.D., Biology, Georgetown University, 1986
  • At Georgetown Since: 1978
  • The lab currently employs a research staff only. Additional grant applications in process to support Post Doctoral Fellows and graduate students.
  • Contact: cotep@georgetown.edu

Details

  • Virology and immunology of hepatitis B virus in humans and model systems (woodchuck hepatitis virus, WHV).
  • Pathogenesis and immunopathogenesis of WHV infection and disease.
  • Antiviral therapy and immunotherapy against WHV.

Virology and immunology of hepatitis B virus in humans and model systems (woodchuck hepatitis virus, WHV).
Pathogenesis and immunopathogenesis of WHV infection and disease.
Antiviral therapy and immunotherapy against chronic WHV infection and disease progression, including liver cancer.

Dr. Cote has been with Georgetown University since 1978. He was active as research faculty in the department since 1987 under Dr. John L. Gerin while his project was centered in Rockville, MD until 2006. Since then he relocated to the Georgetown University Medical Center Campus where he has continued his research work in hepatitis B. Most recently, since 2010, he was awarded a 3-year NIH contract, entitled the “Woodchuck animal model for testing hepatitis B virus therapeutics”, which involves continuing extensive collaboration with his long-time colleague and project Co-PI, Dr. Stephan Menne, who is now a Research Associate Professor in this department since 2010 (see publication listing). Dr. Cote also collaborates with Co-PI, Dr. Jan Gnadt of the Georgetown RRF/DCM to conduct studies in the NIH woodchuck animal model. The group photo below shows the lab and animal study group members currently working under Drs. Cote (standing left) and Menne (standing right).  

Publications

  • Liu KH, Ascenzi MA, Bellezza CA, Bezuidenhout AJ, Cote PJ, Gonzalez-Aseguinolaza G, Hannaman D, Luxembourg A, Evans CF, Tennant BC, Menne S. Electroporation enhances immunogenicity of a DNA vaccine expressing woodchuck hepatitis virus surface antigen in woodchucks. J Virol. 2011 May;85(10):4853-62.
  • Norton PA, Menne S, Sinnathamby G, Betesh L, Cote PJ, Philip R, Mehta AS, Tennant BC, Block TM.Glucosidase inhibition enhances presentation of de-N-glycosylated hepatitis B virus epitopes by major histocompatibility complex class I in vitro and in woodchucks. Hepatology. 2010 Oct;52(4):1242-50.
  • Cote PJ, Butler SD, George AL, Fairman J, Gerin JL, Tennant BC, Menne S. Rapid immunity to vaccination with woodchuck hepatitis virus surface antigen using cationic liposome-DNA complexes as adjuvant. J Med Virol. 2009 Oct;81(10):1760-72.
  • Menne S, Butler SD, George AL, Tochkov IA, Zhu Y, Xiong S, Gerin JL, Cote PJ, Tennant BC. Antiviral Effect of Lamivudine, Emtricitabine, Adefovir Dipivoxil, and Tenofovir Disoproxil Fumarate, Adminstered Orally Alone and in Combination, to Woodchucks with Chronic Woodchuck Hepatitis Virus Infection. Antimicrob Agents Chemother. 2008 Aug 1. [Epub ahead of print]
  • Cullen JM, Lindsey-Pegram D, Cote PJ. Serologic survey of woodchuck hepatitis virus in North Carolina woodchucks (Marmota monax). J Zoo Wildl Med. 2008 Jun;39(2):263-5.
  • Luxembourg A, Hannaman D, Wills K, Bernard R, Tennant BC, Menne S, Cote PJ. Immunogenicity in mice and rabbits of DNA vaccines expressing woodchuck hepatitis virus antigens. Vaccine. 2008 Jul 29;26(32):4025-33. Epub 2008 Jun 2.
  • Menne S, Tennant BC, Gerin JL, Cote PJ. Chemoimmunotherapy of chronic hepatitis B virus infection in the woodchuck model overcomes immunologic tolerance and restores T-cell responses to pre-S and S regions of the viral envelope protein. J Virol. 2007 Oct;81(19):10614-24. Epub 2007 Jul 25.
  • Menne S, Asif G, Narayanasamy J, Butler SD, George AL, Hurwitz SJ, Schinazi RF, Chu CK, Cote PJ, Gerin JL, Tennant BC. Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2007 Sep;51(9):3177-84. Epub 2007 Jul 2.
  • Menne S, Cote PJ, Butler SD, Toshkov IA, Gerin JL, Tennant BC. Immunosuppression reactivates viral replication long after resolution of woodchuck hepatitis virus infection. Hepatology. 2007 Mar;45(3):614-22.
  • Menne S, Cote PJ. The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection. World J Gastroenterol. 2007 Jan 7;13(1):104-24. Review.

Medline publications list