Dr. Cote is a Research Professor of Microbiology & Immunology

Summary:

• M.S., Physiology, Pennsylvania State University, 1977
• Ph.D., Biology, Georgetown University, 1986
• At Georgetown Since: 1978
• The lab currently employes a research staff only. Additional grant applications in process to support Post Doctoral Fellows and graduate students.
• Contact: cotep@georgetown.edu

Details:

• Virology and immunology of hepatitis B virus in humans and model systems (woodchuck hepatitis virus, WHV).
• Pathogenesis and immunopathogenesis of WHV infection and disease.
• Antiviral therapy and immunotherapy against WHV.

Until recently, Dr. Cote was part of the research faculty within the Division of Molecular Virology at the Dept of Microbilogy & Immunology in Rockville, MD. DMVI faculty and research staff have now permanently relocated to the Washington, DC Georgetown University Medical Center Campus.

Over the years, members of the DMVI laboratory have conducted investigations, often involving collaborations with various NIAID scientists, grantees and contractors, in projects involving rhinoviruses, mouse hepatitis virus, influenza viruses (equine and human), parainfluenza 1, 2 & 3 viruses, measles virus, virions of progressive multifocal leukoencephalopathy, agents of nonbacterial gastroenteritis (Norwalk agent and rotaviruses), adenoviruses, vaccinia virus, respiratory syncytial virus, hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus, hepatitis E virus, woodchuck hepatitis virus, human immunodeficiency virus, simian immunodeficiency virus, feline immunodeficiency virus, human herpesvirus-6 and human herpesvirus-7.

The research efforts have ranged from basic virology to studies aimed at defining the natural history of infection and disease, diagnostic methodology, prevention by passive and active immunization and treatment. These activities have resulted in many publications in the scientific literature

Publications:

1) Menne S., P.J. Cote, B.E. Korba, S.D. Butler, A.L. George, I.A. Toshkov, W.E. Delaney IV, S. Xiong., J.L. Gerin, and B.C. Tennant. 2005. Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 49:2720-2728.

2) Korba, B.E., P.J. Cote, I. Toshkov, S. Menne, B.H. Baldwin, F.V. Wells, B.C. Tennant, and J.L. Gerin. 2004. Combined therapy using clevudine and vaccine delays disease onset in chronic woodchuck hepatitis virus infection. Antivir. Ther. 9:937-952.

3) Wang, Y., J. R. Jacob, S. Menne, C. Bellezza, B. C. Tennant, J. L. Gerin, and P. J. Cote. 2004. Role of IFN-ã-associated responses in woodchuck hepatitis virus infection and clearance from hepatocytes. J. Viral Hepatitis 11:404-417.

4) Wang, Y., S. Menne, B.H. Baldwin, B.C. Tennant, J.L. Gerin, and P.J. Cote. 2003. Kinetics of viremia and acute liver injury in relation to outcome of neonatal WHV infection. J. Med. Virol. 72:406-415

5) Wang, Y., S. Menne, J.R. Jacob, B.C. Tennant, J.L. Gerin, and P.J. Cote. 2003. Role of type 1 versus type 2 immune responses in liver during onset of chronic woodchuck hepatitis virus infection Hepatology 37:771-780.

6) Menne, S., C.A. Ronecker, B.E. Korba, J.L. Gerin, B.C. Tennant, and P.J. Cote. 2002. Immunization with surface antigen alone and after treatment with L-FMAU breaks humoral and cellular immune tolerance in chronic woodchuck hepatitis virus infection. J. Virol. 76:5305-5314.

7) Menne, S., C.A. Ronecker, M. Roggendorf, J.L. Gerin, P.J. Cote, and B.C. Tennant. 2002. Deficiencies in the acute phase cell-mediated immune response to viral antigens are associated with development of chronic woodchuck hepatitis virus infection following neonatal inoculation. J. Virol. 76:1769-1780

8) Cote, P.J., I. Toshkov, C. Bellezza, M. Ascenzi, C. Roneker, L.A. Graham, B.H. Baldwin, K. Gaye, I. Nakamura, B.E. Korba, B.C. Tennant, and J.L. Gerin. 2000. Temporal pathogenesis of experimental neonatal woodchcuk hepatitis virus infection: increased initial viral load and decreased severity of acute hepatitis during the development of chronic viral infection. Hepatology 32:807-817.

9) Cote, P.J., B.E. Korba, R.H. Miller, B.H. Baldwin, W.E. Hornbuckle, R.H. Purcell, B.C. Tennant, and J.L. Gerin. 2000. Effects of age and viral determinants on chronicity as an outcome of experimental woodchuck hepatitis virus infection. Hepatology 31:190-200.

10) Cote, P.J. and J.L. Gerin. 1995. In vitro activation of woodchuck lymphocytes measured by radiopurine incorporation assays and IL-2 production: implications for immunity and therapy in HBV infection. Hepatology 22:687-699.

11) Cote, P.J., C. Roneker, K. Cass, F. Schodel, D. Peterson, B. Tennant, F. deNoronha, and J.L. Gerin. 1993. New enzyme immunoassays for the serologic detection of woodchuck hepatitis virus infection. Viral Immunology 6:161-169.

12) Cote, P.J., B.E. Korba, B. Baldwin, W.E. Hornbuckle, B.C. Tennant, and J.L. Gerin. 1992. Immunosuppression with cyclosporine A during the incubation period of experimental woodchuck hepatitis virus infection increases the frequency of chronic infection in adult woodchucks. J. Infect. Dis. 166:628-631.

13) Cote, P.J., B.E. Korba, H. Steinberg, C. Ramirez-Meija, B. Baldwin, W.E. Hornbuckle, B.C. Tennant and J.L. Gerin. 1991. Cyclosporine A modulates the course woodchuck hepatitis virus infection and induces chronicity. J. Immunol. 146:3138-3144.

14) Cote, P.J., J.L. Gerin, and B.C. Tennant. 1990. Serum alphafetoprotein in the woodchuck model of hepadnavirus infection and disease: normal physiologic patterns and responses to woodchuck hepatitis virus infection and hepatocellular carcinoma. Cancer Research 50:7843-7851.

15) Cote, P.J. and J.L. Gerin. 1983. Nonoverlapping antigenic sites of woodchuck hepatitis virus surface antigen and their crossreactivity with ground squirrel hepatitis virus and hepatitis B virus surface antigens. J. Virol. 47:15 23.

 

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