Faculty: Ronald L. Cihlar

Dr. Cihlar is a Professor at the Department of Microbiology & Immunology

Summary:
  • Ph.D., University of Massachusetts, 1978
  • At Georgetown Since: 1981
  • Contact: (202) 687-1136; cihlarr@georgetown.edu  
Details:

My laboratory is examining questions pertaining to the pathogenesis of Candida albicans, as well as performing studies aimed at antifungal drug discovery. In particular, we are:

Investigating genes that may prove to be appropriate targets useful in the development of new antifungal agents. Work entails gene isolation/functional characterization and target validation through gene knockout studies.
Studying the effects on nitric oxide- generating compounds, natural products, and designed chemical compounds on fungal growth and physiology.

Publications:
  • Maisuria BB, Actis ML, Hardrict SN, Falkinham JO 3rd, Cole MF, Cihlar RL, Peters SM, Macri RV, Sugandhi EW, Williams AA, Poppe MA, Esker AR, Gandour RD. Bioorg Med Chem. 2011 May 1;19(9):2918-26. Epub 2011 Apr 12. Comparing micellar, hemolytic, and antibacterial properties of di- and tricarboxyl dendritic amphiphiles.
  • Cihlar RL, Calderone RA.
  • Methods Mol Biol. 2009;499:v. Candida albicans: methods and protocols. Preface.
  • Krom BP, Cohen JB, McElhaney-Feser G, Busscher HJ, van der Mei HC, Cihlar RL. Methods Mol Biol. 2009;499:55-62. Conditions for optimal Candida biofilm development in microtiter plates.
  • Krom BP, Cohen JB, McElhaney Feser GE, Cihlar RL. J Microbiol Methods. 2007 Feb;68(2):421-3. Epub 2006 Sep 26. Optimized candidal biofilm microtiter assay.
  • Kruppa M, Krom BP, Chauhan N, Bambach AV, Cihlar RL, Calderone RA. Eukaryot Cell. 2004 Aug;3(4):1062-5. The two-component signal transduction protein Chk1p regulates quorum sensing in Candida albicans.
  • Krueger KE, Ghosh AK, Krom BP, Cihlar RL. Microbiology. 2004 Jan;150(Pt 1):229-40. Deletion of the NOT4 gene impairs hyphal development and pathogenicity in Candida albicans.
  • Laakso JA, Raulli R, McElhaney-Feser GE, Actor P, Underiner TL, Hotovec BJ, Mocek U, Cihlar RL, Broedel SE Jr. J Nat Prod. 2003 Aug;66(8):1041-6. CT2108A and B: New fatty acid synthase inhibitors as antifungal agents.
  • Zhang Z, ElSohly HN, Li XC, Khan SI, Broedel SE Jr, Raulli RE, Cihlar RL, Burandt C, Walker LA. J Nat Prod. 2003 Apr;66(4):548-50. Phenolic compounds from Nymphaea odorata.
  • Zhang Z, ElSohly HN, Li XC, Khan SI, Broedel SE Jr, Raulli RE, Cihlar RL, Walker LA. J Nat Prod. 2003 Jan;66(1):39-41. Flavanone glycosides from Miconia trailii.
  • Li XC, Joshi AS, ElSohly HN, Khan SI, Jacob MR, Zhang Z, Khan IA, Ferreira D, Walker LA, Broedel SE Jr, Raulli RE, Cihlar RL. J Nat Prod. 2002 Dec;65(12):1909-14. Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.

Medline publications list