Dr. Kerr is an Adjunct Professor of Microbiology & Immunology at Georgetown University Medical Center.

Summary:

• PhD, Vanderbilt University School of Medicine, 1990
• At Georgetown Since: 2005
• No lab capacity
• Contact: lawredk@dni.gov

Dr. Lawrence D. Kerr (Larry) is the Senior Bio Advisor to the Director of the National Counterproliferation Center (NCPC) within the Office of the Director of National Intelligence (ODNI). Before joining NCPC in April 2006, he was Director for Biodefense Policy with the Homeland Security Council in the Executive Office of the President (EOP). He has served as Assistant Director for Homeland Security for the Office of Science and Technology Policy (OSTP) within EOP. Prior to this position, he served as Director of Bioterrorism, Research and Development for the Office of Homeland Security (OHS) in the EOP. Before joining OHS, he was a National Institutes of Health (NIH) agency representative to the National Science and Technology Council (NSTC) in the OSTP. Dr. Kerr joined the Life Sciences division of OSTP in January 2001. He came from his position as Chief of Transplantation, Transplantation and Immunology Branch at the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health (NIH).

As an Assistant Professor in Microbiology and Immunology at Vanderbilt School of Medicine in Nashville TN, Dr. Kerr ran a basic science laboratory devoted to the study of the transcriptional regulation of gene products involved in HIV replication and breast cancer development. He has lectured at the national and international levels and received awards for teaching excellence. He is the author of more than 50 peer-reviewed articles, reviews and book chapters.

Recent Publications:

Bushdid, P., Brantley, D. M., Yull, F.E., Blaeuer, G.E., Hoffman, L., Niswander, L., and Kerr, L.D. 1998. Inhibition of NF-kB activity results disruption of the apical ectodermal ridge and aberrant limb morphogenesis. Nature (392) 615-618.

Chen, C.-L., Yull, F.E., and Kerr, L.D. 1999. Differential serine phosphorylation regulates IkB-a inactivation. Biochem Biophys. Res. Comm. 257(3): 798-806.

Sohur, U. S., Dixit, M.N., Chen, C.-L., Byrom, M., Reed, J.C., and Kerr, L.D. 1999. Rel/NF-kB represses bcl-2 transcription in pro-B lymphocytes. Gene Expression 8(4): 219-229.

Connolly, J.L., Rodgers, S.E., Clarke, P., Ballard, D.W., Kerr, L.D., Tyler, K.L., and Dermody, T.S. 2000. Reovirus-induced apoptosis requires activation of transcription factor NF-kB. J. Virol. 74(7): 2981-2989.

Sohur, U. S., Chen, C.-L., Hicks, D.J., Yull, F.E., and Kerr, L.D. 2000. NF-kB/cRel is apoptogenic in cytokine-withdrawal programmed cell death.. Cancer Research 60(5): 1202-1205.

Chen, C.-L., Singh, N., Yull, F.E., Strayhorn, D., Van Kaer, L., and Kerr, L.D. 2000. Lymphocytes lacking IkappaB-alpha develop normally, but have selective defects in proliferation and function. J. Immunol. 165(10): 5418-5427.

Brantley, D. M., Yull, F.E., Muraoka, R. S., Hicks, D., Cook, C. M., and Kerr, L. D. 2000. Dynamic expression and activity of NF-kappaB during post-natal mammary gland morphogenesis. Mech. Dev. 97(1-2): 149-155.

Muraoka, R.S., Bushdid, P. B., Brantley, D. M., Yull, F. E., and Kerr, L.D. 2000. Mesenchymal expression of nuclear factor-kappaB inhibit epithelial growth and branching in the embryonic chick lung. Develop. Biol. 225(2): 322-338.

Brantly, D.M., Chen, C.L., Muraoka, R.S., Bushdid, P.B., Bradberry, J.L., Kitrell, F., Medina, D., Matrisian, L.M., Kerr, L.D. and Yull, F.E. 2001. Nuclear Factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium. Mol. Biol. Cell. 12(5): 1445-1455.

Chen, C.-L., Yull, F.E., Cardwell, N., Singh, N., Strayhorn, D., Nanney, L., and Kerr, L.D. 2001. RAG2-/-, IkB-a- /- chimeras display a psoriasiform skin disease. J, Invest. Dermatol. 115(6): 1124-1133.