Georgetown Medical Culpula

Faculty: Paul J. Cote

Dr. Cote is a Research Professor of Microbiology & Immunology


Summary: 

  • M.S., Physiology, Pennsylvania State University, 1977
  • Ph.D., Biology, Georgetown University, 1986
  • At Georgetown Since: 1978
  • The lab currently employs a research staff only. Additional grant applications in process to support Post Doctoral Fellows and graduate students.
  • Contact: cotep@georgetown.edu

 

Details: 

  • Virology and immunology of hepatitis B virus in humans and model systems (woodchuck hepatitis virus, WHV).
  • Pathogenesis and immunopathogenesis of WHV infection and disease.
  • Antiviral therapy and immunotherapy against WHV.

Until recently, Dr. Cote was part of the research faculty within the Division of Molecular Virology at the Dept of Microbilogy & Immunology in Rockville, MD. DMVI faculty and research staff have now permanently relocated to the Washington, DC Georgetown University Medical Center Campus.

Over the years, members of the DMVI laboratory have conducted investigations, often involving collaborations with various NIAID scientists, grantees and contractors, in projects involving rhinoviruses, mouse hepatitis virus, influenza viruses (equine and human), parainfluenza 1, 2 & 3 viruses, measles virus, virions of progressive multifocal leukoencephalopathy, agents of nonbacterial gastroenteritis (Norwalk agent and rotaviruses), adenoviruses, vaccinia virus, respiratory syncytial virus, hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus, hepatitis E virus, woodchuck hepatitis virus, human immunodeficiency virus, simian immunodeficiency virus, feline immunodeficiency virus, human herpesvirus-6 and human herpesvirus-7.

The research efforts have ranged from basic virology to studies aimed at defining the natural history of infection and disease, diagnostic methodology, prevention by passive and active immunization and treatment. These activities have resulted in many publications in the scientific literature.
 



Publications:

  • Menne S, Butler SD, George AL, Tochkov IA, Zhu Y, Xiong S, Gerin JL, Cote PJ, Tennant BC. Antiviral Effect of Lamivudine, Emtricitabine, Adefovir Dipivoxil, and Tenofovir Disoproxil Fumarate, Adminstered Orally Alone and in Combination, to Woodchucks with Chronic Woodchuck Hepatitis Virus Infection. Antimicrob Agents Chemother. 2008 Aug 1. [Epub ahead of print]
  • Cullen JM, Lindsey-Pegram D, Cote PJ. Serologic survey of woodchuck hepatitis virus in North Carolina woodchucks (Marmota monax). J Zoo Wildl Med. 2008 Jun;39(2):263-5.
  • Luxembourg A, Hannaman D, Wills K, Bernard R, Tennant BC, Menne S, Cote PJ. Immunogenicity in mice and rabbits of DNA vaccines expressing woodchuck hepatitis virus antigens. Vaccine. 2008 Jul 29;26(32):4025-33. Epub 2008 Jun 2.
  • Menne S, Tennant BC, Gerin JL, Cote PJ. Chemoimmunotherapy of chronic hepatitis B virus infection in the woodchuck model overcomes immunologic tolerance and restores T-cell responses to pre-S and S regions of the viral envelope protein. J Virol. 2007 Oct;81(19):10614-24. Epub 2007 Jul 25.
  • Menne S, Asif G, Narayanasamy J, Butler SD, George AL, Hurwitz SJ, Schinazi RF, Chu CK, Cote PJ, Gerin JL, Tennant BC. Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2007 Sep;51(9):3177-84. Epub 2007 Jul 2.
  • Menne S, Cote PJ, Butler SD, Toshkov IA, Gerin JL, Tennant BC. Immunosuppression reactivates viral replication long after resolution of woodchuck hepatitis virus infection. Hepatology. 2007 Mar;45(3):614-22.
  • Menne S, Cote PJ. The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection. World J Gastroenterol. 2007 Jan 7;13(1):104-24. Review.
  • Casey J, Cote PJ, Toshkov IA, Chu CK, Gerin JL, Hornbuckle WE, Tennant BC, Korba BE. Clevudine inhibits hepatitis delta virus viremia: a pilot study of chronically infected woodchucks. Antimicrob Agents Chemother. 2005 Oct;49(10):4396-9.
  • Menne S., P.J. Cote, B.E. Korba, S.D. Butler, A.L. George, I.A. Toshkov, W.E. Delaney IV, S. Xiong., J.L. Gerin, and B.C. Tennant. Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49(7):2720-8.
  • Korba, B.E., P.J. Cote, I. Toshkov, S. Menne, B.H. Baldwin, F.V. Wells, B.C. Tennant, and J.L. Gerin. Clevudine therapy with vaccine inhibits progression of chronic hepatitis and delays onset of hepatocellular carcinoma in chronic woodchuck hepatitis virus infection. Antivir Ther. 2004 Dec;9(6):937-52.

Medline publications list