Dr. Dongmei Li is Assistant Professor at the Department of Microbiology & Immunology

 

Summary:

• Ph.D, Medical Microbiology, 1995
• At Georgetown Since: 2000
• Lab capacity for new students?: No
• Contact: dl33@georgetown.edu

Research Interest:

Dr. Li's professional expertise is mainly in the fields of clinical mycology and molecular mycology. She has more than ten years of experience working in the clinical mycology field, such as diagnosis of patient as a clinician and identification of pathogenic fungi in the clinical microbiologic lab as a mycologist. Since 1998, Dr. Li has been working in molecular biology lab, studying pathogenesis of medical fungi.

Her primary research focus is on pathogenesis of a medically important pathogen, Candida. She has also been evaluating the role of two-component histidine kinase and regulator signal protein, CHK1, SSK1 in pathogenesis of candidiasis by their mutants morphogenesis and animal virulent in vivo.

Publications:

1. Li, D.M., Horie, Y., Wang, Y., and Li, R. (1998) Three new Aspergillus species isolated from clinical sources as a causal agent of human aspergillosis. Mycoscience 39:299-305.
2. Li, D.M., Li, N., Ma, B., Mayfield, M.B., and Gold, M.H. (1999) Characterization of genes encoding two manganese peroxidases from the lignin-degrading fungus Dichomitus squalens. Biochem. Biophys. Acta 1434:356-364.
3. Luo, Z. C., Wang, D.L., Li, R.Y., Li, S.Y., Kong, F. R., Li, D. M.(2000) Cloning and sequencing of the ITS in rDNA gene of Aspergillus fumigatus. Mycosystema 19:336-341.
4. Li, D.M., Youngs, H. L., and Gold, M. H. (2001) Heterologous expression of a thermostable manganese peroxidase from Dichomitus squalens in Phanerochaete chrysosporium. Arch. Biochem. Biophys. 385 (2): 348-356.
5. Li, D.M. (2002) The cell wall of Candida spp. Candida and Candidiasis.159-171. In R.A. Calderone (ed.), Candida, ASM Press.
6. Li, D.M. Bernhardt J., and Calderone, R. (2002) Temporal expression of the Candida albicans genes CHK1 and CSSK1, Adherence, and Morphogenesis in a model of reconsitituted human esophageal epithelial candidiasis. Infect. Immun. 70(3):1558-1565.
7. Chauhan, N., Inglis, D., Roman, E., Pla, J., Li, D.M., Calera, J. A., Calderone, R.(2003) Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress. Eukaryotic Cell. 2(5):1018-1024
8. Li, D.M. and Calderone R.A. (2003) Pathogenic fungi host interactions and emerging strategies for control. 335-356. In G. San-Blas and R.A. Calderone., (ed.)
9. Li, D.M., Gurkovska, V., Sheridan, M., Calderone R.A. (2004) Studies on the regulation of the two component histidine kinase gene CHK1 in Candida albicans using the heterologous lacZ-reporter gene. Microbiology 150:3305-3313
10. Menon V., Li, D.M., Richard Calderone. (2006) Functional studies of the Ssk1p response regulator protein of Candida albicans as determined phenotypic analysis of receiver domain point mutants. Molecular Microbiology (under read proof)